Abstract
Individuals with SLE have a heightened risk of developing atypical cervical smears or cervical cancer. Many studies have investigated the association between SLE and cervical neoplasia risk. However, the risk for SLE associated with cervical neoplasia risk is unclear. The present meta-analysis clarified the risk of cervical neoplasia in patients with SLE. A systematic review of English-language studies was conducted. Data on the risk of cervical neoplasia risk in patients with SLE were pooled using case-control models. Replication studies that tested the association between SLE and cervical neoplasia risk were reviewed for meta-analysis. The meta-analysis procedure was used to pool odds ratios (ORs) with 95% CIs to evaluate the association. Seven replication studies fulfilled the selection criteria for inclusion in the meta-analysis. Homogeneity was confirmed across the replication studies. The common OR was 4.17 (95% CI 3.03, 5.74; P < 0.00001) for the study. The association was confirmed when individuals with SLE have an increased susceptibility to cervical neoplasia risk. This meta-analysis demonstrates the positive association between SLE and cervical neoplasia risk. Individuals with SLE have a heightened risk of developing cervical cancer.
Highlights
Cervical cancer is the second most commonly occurring cancer in women and accounts for up to 300 000 annual deaths [1]
Individuals with SLE have a heightened risk of developing atypical cervical smears or cervical cancer
Replication studies that tested the association between SLE and cervical neoplasia risk were reviewed for meta-analysis
Summary
Cervical cancer is the second most commonly occurring cancer in women and accounts for up to 300 000 annual deaths [1]. Along with a high infection rate of HPV in SLE patients, many studies have shown an increased incidence of cervical cancer in SLE patients and other studies have noted a high risk of abnormal Pap tests in women with SLE. Research has shown that SLE syndrome represents a permissive effect of immunosuppression on increased host susceptibility to high cancer-risk HPV infections, the causative agents of SIL and cervical cancer [2, 7, 8, 13, 14]. One study showed an increased incidence of cervical cancer in SLE and other studies have noted a high risk of abnormal Pap tests in women with SLE [15]. The current study was designed to evaluate the relationship between SLE and cervical cancer risk through meta-analysis using previous relevant studies
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