Abstract
Purpose Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 56708 controls, were identified to estimate their association with 12 AD subtypes. Methods Several electronic databases were searched to analyze population-based studies on the relationship between miRNA variants and AD risk. Fixed effects or random effect models were used in the meta-analysis for the risk assessment. Results In our meta-analysis, miR-146a rs2910164/rs57095329 conferred a marginally elevated risk for AD (allele model, OR = 1.08, 95% CI: 1.01-1.15, P = 0.019; allele model, OR = 1.09, 95 CI: 1.05-1.15, P < 0.001, respectively). Furthermore, miR-196a2 rs11614913 was also associated with AD risk (allele model, OR = 0.92, 95% CI: 0.88-0.97, P = 0.001) as well as miR-499 rs3746444 (allele model, OR = 1.16, 95% CI: 1.03-1.29, P = 0.011). In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15, 95% CI: 1.06-1.24, P < 0.001; allele model, OR = 1.11, 95% CI:1.01-1.22, P = 0.043, respectively). Conclusions Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD.
Highlights
Autoimmune diseases (AD) are a spectrum of disorders initiated by impaired self-tolerance of the immune system and may lead to tissue destruction, chronic inflammation, and morbidity [1]
These findings indicate that variants in common miRNAs could be genetic markers of AD such as multiple sclerosis, rheumatoid arthritis, and ankylosing spondylitis, which highlighted a new paradigm for genetic susceptibility
After a careful choice of papers following review of titles, abstracts, and key terms related to miRNA-single nucleotide polymorphisms (SNPs) or AD, 3983 studies were deleted for not addressing neither miRNA-SNP nor AD, and 150 full-text articles were identified to be potentially relevant
Summary
Autoimmune diseases (AD) are a spectrum of disorders initiated by impaired self-tolerance of the immune system and may lead to tissue destruction, chronic inflammation, and morbidity [1]. Recent studies suggested that functional variants occurring in microRNA sequences were associated with susceptibility to AD [6,7,8,9,10,11,12,13,14,15]. These findings indicate that variants in common miRNAs could be genetic markers of AD such as multiple sclerosis, rheumatoid arthritis, and ankylosing spondylitis, which highlighted a new paradigm for genetic susceptibility
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