Abstract
Objective To compare the therapeutic effect of brachytherapy and radical prostatectomy for localized prostate cancer using a Meta-analysis.Methods The published data with randomized control trials (RCT) on comparison of brachytherapy and radical prostatectomy for the treatment of localized prostate cancer in PubMed,Wanfang database,Chinese Biomedical Literature Database ( CBMdisc),the Excerpta Medica Database (EMBASE),Ovid and Cochrane library were searched and screened.The quality of the studies included was evaluated and the data with 5-year event free survival rate for comparison were extracted.Meta-analysis was performed by RevMan 5.0 (Cochrane reviews software).Results From six trials,there were 5903 patients that were eligible for the analysis,in which 3323 patients were treated by brachytherapy and other 2580 by radical prostatectomy.The odds ratio of all trials was 1.00 (95％ CI:0.69-1.45,P =0.99 ) and there was no significant difference of 5-year event free survival rate between two treatment groups.Conclusion This Meta analysis shows that brachytherapy may have comparable treatment effect than radical prostatectomy. Key words: Prostatic neoplasms; Brachytherapy; Surgery, operative; Treatment outcome; Meta-analysis
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