Meta-Analysis of Bilateral Versus Single Internal Thoracic Artery Grafting in Patients ≥70 Years of Age

Abstract

The optimal choice of graft material in patients ≥70years of age undergoing coronary artery bypass grafting remains unknown. A systematic review of literature was conducted by searching PubMed, Embase, Web of Science, and Cochrane Library databases for original publications that compared bilateral internal thoracic artery (BITA) grafting with single internal thoracic artery grafting in patients ≥70years of age. Data were extracted by 2 independent investigators and meta-analyzed with the use of random effects. A total of 10 studies, including 11,185 patients, met the inclusion criteria. No differences in early mortality and morbidity, with the exemption of sternal wound complications which were more frequently observed in the BITA group (odds ratio 1.72, 95% 1.00 to 2.96 confidence interval [CI], p=0.05; propensity score-matched population odds ratio 1.58, 95% CI 1.09 to 2.29, p=0.02), were observed. Overall survival was superior in the overall patient population (hazard ratio [HR] 0.76, 95% CI 0.66 to 0.86, p <0.001), after applying a blanking period of 3months to the overall patient population (HR 0.77, 95% CI 0.64 to 0.92, p=0.005) as well as in the matched population (HR 0.72, 95% CI 0.58 to 0.89, p=0.002); in all cases, a benefit was readily seen within a few years after surgery. The difference in freedom from major adverse cardiac and cerebrovascular events failed to reach statistical significance (overall patient population HR 0.55, 95% CI 0.27 to 1.13, p=0.10; matched population HR 0.52, 95% CI 0.23 to 1.16, p=0.11). In conclusion, BITA grafting can be safely performed in patients ≥70years of age as late clinical benefits are expected to manifest themselves readily within a few years after surgery.