Abstract
Objective: In a previous study we have demonstrated that soluble factors present in menstrual effluent are able to induce morphological changes in mesothelial cells. The epitheloid morphology of the mesothelial monolayer changed into a fibroblastoid phenotype. Apparently, these factors initiate a process of cell remodelling in monolayers of mesothelial cells. It is assumed that endometrial cell attachment and growth of ectopic foci is facilitated, if menstrual effluent in vivo has a disrupting effect on the mesothelial layer. Inflammatory cells also activated during menstruation, might contribute to the formation of ectopic foci by means of mesothelial injury. In order to better understand the pathogenesis of endometriosis, we aim in this study to further identify these soluble injury factors in menstrual effluent.
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