Abstract
The aim of this study was to evaluate a therapeutic efficacy of allogenic mesenchymal bone marrow stem cells (MSCs) (5 million / ml dose) in combination with specific therapy in experimental female genital tuberculosis (20 female “Chinchilla” rabbits). It has been shown that on the background of specific therapy the injection of MSCs actively affects reparative processes and promotes reepithelialization of the fallopian tubes 2 months after the inoculation. An active position of myofibroblasts differentiating from the MSC in the reparative reaction and promoting a normalization of epithelium and connective tissue relations was registered. At the same time, the introduction of a new antituberculous drug - tioureidoiminomethylpyridinium perhlorate (perhlozon) to the specific treatment, was contributed to a restoration of structural and functional integrity of the fallopian tubes, by reinforcing the effect of etiotropic substances and by accelerating abacillation. (For citation: Ariel BM, Guseinova FM, Vinogradova TI, et al. Mesenchymal stem cells of the bone marrow in treatment of genital tuberculosis in rabbits (experimental research with morphological control). Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(2):47-55. doi: 10.17816/RCF15247-55).
Highlights
The background of specific therapy the injection of marrow stem cells (MSCs) actively affects reparative processes and promotes reepithelialization of the fallopian tubes 2 months after the inoculation
An active position of myofibroblasts differentiating from the MSC in the reparative reaction and promoting a normalization of epithelium and connective tissue relations was registered
Морфо- и патогенез туберкулеза женских гениталий до конца не изучен, экспериментальных исследований крайне мало [1]
Summary
МЕЗЕНХИМНЫЕ КЛЕТКИ СТРОМЫ КОСТНОГО МОЗГА ПРИ ТУБЕРКУЛЕЗЕ ГЕНИТАЛИЙ У КРОЛИКОВ (ЭКСПЕРИМЕНТАЛЬНОЕ ИССЛЕДОВАНИЕ С МОРФОЛОГИЧЕСКИМ КОНТРОЛЕМ). Для цитирования: Ариэль Б.М., Гусейнова Ф.М., Виноградова Т.И., и др. Мезенхимные клетки стромы костного мозга при туберкулезе гениталий у кроликов (экспериментальное исследование с морфологическим контролем) // Обзоры по клинической фармакологии и лекарственной терапии. Резюме Целью данного исследования явилась оценка терапевтической эффективности использования аллогенных мезенхимных клеток стромы костного мозга (МСК) (5 млн/мл однократно) в сочетании со специфической терапией при экспериментальном туберкулезе женских гениталий (20 кроликов породы шиншилла). MESENCHYMAL STEM CELLS OF THE BONE MARROW IN TREATMENT OF GENITAL TUBERCULOSIS IN RABBITS (EXPERIMENTAL RESEARCH WITH MORPHOLOGICAL CONTROL). For citation: Ariel BM, Guseinova FM, Vinogradova TI, et al Mesenchymal stem cells of the bone marrow in treatment of genital tuberculosis in rabbits (experimental research with morphological control).
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