Abstract
Polystyrene grafted polypropylene MicroTube TM reactors (length × OD, 25 × 5 mm) have been functionalized with chloromethyl groups (Merrifield-type) using chloromethyl methyl ether and Lewis acid catalysts. A potentiometric method using a chloride ion selective electrode has been developed to measure the loading of the Merrifield MicroTube TM reactors. A typical loading of 25–35 μmol/tube for Merrifield MicroTube TM reactors has been achieved. Several reactions performed on Merrifield MicroTube TM reactors demonstrated that they are excellent supports for solid phase synthesis. As a result of the ease with which radiofrequency memory tags can be associated with and separated from the supports, these MicroTube TM reactors can facilitate the synthesis of combinatorial libraries.
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