Mentalizing About Dynamic Social Action Sequences Is Supported by the Cerebellum, Basal Ganglia, and Neocortex: A Meta-Analysis of Activation and Connectivity.

Abstract

The posterior cerebellum and anterior basal ganglia are critical subcortical structures for learning and identifying dynamic action sequences, in concert with the neocortex. The present analysis investigates the role of action sequences during social mentalizing, termed here dynamic or sequential social mentalizing. Although the role of the cerebellum in dynamic social mentalizing was extensively investigated during the last decade, the basal ganglia were long ignored. We conducted an activation likelihood estimation coordinate-based meta-analysis of sequential social mentalizing tasks (with 485 participants in 17 studies). These tasks required participants to make social mentalizing inferences ranging from low-level goals to high-level beliefs and traits, while either memorizing, generating or predicting temporal sequences of the social actions involved (i.e., social sequencing condition), or not (i.e., social non-sequencing control condition), or did so for nonsocial objects (i.e., nonsocial sequencing control condition). The tasks also occasionally included inconsistencies in social behavior. Results revealed that the cerebellum exhibited a preference for social, sequencing, and inconsistent information, while the basal ganglia showed a preference for sequencing and inconsistency, without a general preference for social input. Meta-analytic connectivity analysis further showed evidence of coactivation between mentalizing areas of the cerebellum, basal ganglia and cerebral neocortex. The present work underscores the role of subcortical structures in social mentalizing about dynamic action sequences.