Abstract
Background: Our previous study of the lipid peroxidation and antioxidant defense system (LPO-AOS) state in women with chronic viral hepatitis (CVH) showed the content of fat-soluble vitamin alpha tocopherol significant reduction. Reproductive health of women with CVH needs special attention. The objectives of this study was to determine the frequency of menstrual disorders in the group of women with CVH with marked alpha tocopherol insufficiency.
 Study Design: A case-control study.
 Place and Duration of Study: A study was conducted at Scientific Centre for Family Health and Human Reproduction Problems and in the hepatological department of the Irkutsk clinical hospital of infectious diseases from 2010 to 2014. This work was performed with the use of equipment of Collective research centre “Center for the development of progressive personalized technologies for health” SC FHHRP, Irkutsk.
 Methods and Results: Our study included 44 reproductive age women with CVH and comparable age 28 healthy women. All women underwent clinical examination and questionary survey. We found alpha tocopherol insufficiency in 95.5% cases of patients with CVH and menstrual disorders.
 Conclusion: Our results suggest that menstrual disorders in patients with CVH may be associated with alpha tocopherol insufficiency.
Highlights
Our results suggest that menstrual disorders in patients with chronic viral hepatitis (CVH) may be associated with alpha tocopherol insufficiency
Considering the significant influence of alpha-tocopherol on different parts of the reproductive system [9,10], we assessed the frequency of menstrual disorders in the group of patients with chronic viral hepatitis with marked alpha tocopherol insufficiency
In our previous studies of lipid peroxidation and antioxidant defense system (LPO-AOS) processes we found that women with chronic viral hepatitis had marked decrease in fat-soluble vitamin – alpha-tocopherol [6,7]
Summary
One of the essential characteristics of hepatitis C is that patients develop a chronic form in 60-70% of cases [2]. We believe that determination of the major criteria to assess menstrual disorder risks in reproductive women with chronic viral hepatitis is a crucial task. Our previous study of the lipid peroxidation and antioxidant defense system (LPOAOS) state in women with chronic viral hepatitis (CVH) showed the content of fat-soluble vitamin alpha tocopherol significant reduction. The objectives of this study was to determine the frequency of menstrual disorders in the group of women with CVH with marked alpha tocopherol insufficiency. We found alpha tocopherol insufficiency in 95.5% cases of patients with CVH and menstrual disorders
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