Abstract
Background Chronic viral hepatitis B and C represent a serious medical and social problem, due to their widespread, severe course and significant rejuvenation of the main groups of patients. Currently, sharp increase of chronic forms of hepatitis incidence recorded mainly due to active involvement of reproductive age women in epidemic process. Lipid peroxidation and antioxidant defense system (POL-AOD) playing important place in adaptive reactions, reduction of inflammatory processes and pathology activity and homeostasis maintaining. Because of that, the aim of this study was to analyze peculiarities of POL-AOD parameters changes in women of reproductive age with chronic viral hepatitis B and C. Methods The study included 44 patients (mean age 28,8±7,5 years) with chronic viral hepatitis B (20 patients-45%) and C (24 patients -55%). The control group (mean age 30,8±2,9 years) consisted of 28 healthy women. Spectrophotometric and fluorimetric methods were carried out on Shimadzu RF-1501 spectrofluorophotometer (Japan) and Shimadzu RF-1650 spectrophotometer (Japan) used to investigate lipid peroxidation products and antioxidant defense components in serum and hemolysate. Results The results showed that women with chronic viral hepatitis have statistically significant 1.9 times (p=0,006) increase of POL end-of TBA-active products compared to control values. No statistically significant differences of lipid peroxidation primary products - diene conjugates revealed (p>0,05). The AOD system in women with chronic viral hepatitis in comparison with the control showed 39% decrease (p Conclusion In the course of chronic viral hepatitis the inflammatory process in the liver leads to the generation of reactive oxygen species, initiating lipid peroxidation processes, significant intensification of oxidative stress reactions accompanied by simultaneous inhibition of the antioxidant defense system functions. Data obtained prove the necessity of more thorough approach in diagnostic and therapeutic activities in such patients.
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