Memory enhancement by administration of ginger (Zingiber officinale) extract on morphine-induced memory impairment in male rats

Abstract

To study the chronic treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would effect on the passive avoidance learning (PAL) and memory in rat. MethodsThe rats were divided into eight groups. On the training trial, the mice received an electric shock when the animals were entered into the dark compartment. Twenty-four hours later, 30 min after treatment, the STL (step-through latency) and TDC (total time in dark compartments) was recorded and defined as the retention trial. ResultsThe time latency in morphine-treated group was lower than control (P<0.001). Treatment of the animals by 100 and 200 mg/kg of ginger extract before the training trial increased the time latency at 24 hours after the training trial (P<0.01 and P<0.001). Administration of both 100 and 200 mg/kg doses of the extract in morphine received animal groups before retention trials also increased the time latency than the morphine-treated group groups (P<0.001). ConclusionThe results revealed that the ginger extract attenuated morphine-induced memory impairment.