Meme Koruyucu Cerrahi Sonrası (MKC) Simultane İntegre Boost (SIB) Tekniğinin Farklılığı

Abstract

Whole breast irradiation after breast conserving surgery (BCS) is the standard treatment for early stage breast cancer. For early-stage breast cancer, breast-conserving surgery and subsequent postoperative radiotherapy are as effective as mastectomy. An early stage 10 breast cancer patient admitted to the Radiation Oncology Clinic of Sisli Hamidiye Etfal Training and Research Hospital was included in the study. The study is a retrospective study and patients were not treated with the plans and techniques used in the studies. In the study, the planning target volume (PTV) and the organs at risk (OAR) planned with Sequential Intensity Modulated Radiotherapy (IMRT) and Simultaneous Integrated Supplement (Boost) Intensity Modulated Radiotherapy (SIB IMRT) techniques in patients who have undergone breast conserving surgery due to breast cancer. It is aimed to be compared dosimetrically. For the study, patients with consecutive IMRT were given 50 Gy / 25 fraction to the whole breast and 10 Gy / 5 fraction to the boost area, while patients with SIB IMRT were given a total of 50.4 Gy / 28 fractions to the entire breast, while additional dose to the boost volume was given 60 Gy / 28 fraction dose. Ipsilateral lung, heart, the minimum and maximum doses of the PTV breast and PTV boost areas and the homogeneity index (HI), conformity index (CI) values were matched with the help of the t - test minitab program. SIB IMRT technique and Sequential IMRT technique the ipsilateral lung; When the average doses of V5 value for 10 patients are compared, the results are not statistically significant, while the V20 value is statistically significant when the average dose values for 10 patients are compared, it has been demonstrated that SIB IMRT technique can be performed with a lower dose in the ipsilateral lung V20. When the heart average and heart V20 values are compared for the two techniques, the SIB IMRT technique was not statistically significant, and it has no superiority over the Sequential IMRT technique. While dose homogeneity was better with SIB IMRT in whole breasts, there was no difference in boost area homogeneity and whole breast conformity index SIB IMRT technique for decreasing excess normal tissue volumes irradiated, shortening the treatment process, dose reduction in organs at risk, reducing the dose per fraction for the breast and increasing the dose per fraction to the boost area due to the low incidence of acute skin toxicity, standard use in breast protector RT it can be recommended for.