Abstract
A mathematical model of the neurone has been developed using the method of subdivision of the neurone into a number of equivalent circuit compartments. Compartmental characteristics have been investigated by calculating the shape indices of the output produced in response to a given somatic input conductance change. A generalised form of compartmental chain has been chosen to allow calculation of the shape indices produced by a variety of geometrical configurations including the straight and tapering chain forms. Equations have been deduced from the computations made on a CDC 6600 computer relating the peak amplitude of the output response to the compartmental diameter for both the straight and tapering chain forms. The effect of variation in the location of the input conductance injection site has also been related to the peak amplitude of the somatic response. The optimum characteristics of the input conductance pulse shape have been computed initially using a rectangular pulse and later the more physiologically relevant double exponential shape. The effect of alteration in the end compartmental terminal impedances over the range from open to short circuit conditions was also calculated. The establishment of optimum single compartmental chain criteria allows the future investigation of multiple chain and pyramidal cell configurations.
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