Abstract
Amphipathic copolymers such as styrene-maleic acid (SMA) [1,2] and more recently diisobutylene-maleic acid (DIBMA) [3] are gaining attention due to their ability to spontaneously solubilize lipid bilayers into discoidal nanoparticles. As such they are convenient tools to isolate and study membrane proteins within their native lipid environment. For SMA copolymers it has been shown that average length and composition of the copolymers are important parameters in determining the efficiency of solubilization and properties of the resulting nanodiscs.
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