Abstract
Progesterone maintains pregnancy by promoting myometrial quiescence through genomic and non-genomic pathways and labor is initiated by progesterone withdrawal. The role of non-genomic progesterone actions in human pregnancy and parturition are not clearly understood. Non-genomic progesterone actions are mediated by membrane-bound PRs (mPRs): mPRα, mPRβ, mPRγ, and progesterone receptor membrane components -1 and -2 (PGRMC-1 and PGRMC-2). The goal of this study was to measure the extent of mPR expression in the term human myometrium and determine whether levels change in association with the onset of labor.
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