Abstract
Two groups of individuals, 26 normotensive normolipemic and 37 normotensive hyperlipemic, all without family hystory of hypertension have been selected in attempt to demonstrate whether LiNa countertransport of erythrocytes is influenced by plasma and membrane lipid composition. The maximal rate of LiNa countertransport was elevated in hyperlipemics (0.344±0.168 vs 0.220±0.074 mmol/l erythrocytes/h). This difference is highly significant. Hyperlipemics had different composition of membrane lipids than normals. The most important variations were: increase of palmitic, palmitoleic and total saturated fatty acids (SFA) as well as increase of cholesterol/phospholipids ratio (C/PL); in contrast, hyperlipemics had a reduced amount of linoleic acid and total unsaturated fatty acids (UFA) as well as total polyunsaturated fatty acids (PUFA). Consequently, UFA/SFA and PUFA/SFA ratios were lower than in normals. LiNa countertransport was negatively correlated with the amount of PUFA (p<0.02), whereas it was positively correlated with the following parameters: oleic/linoleic ratio (p <0.02), monounsaturated fatty acids/polyunsaturated fatty acids ratio (p <0.03) as well as with the SFA+monounsaturated fatty acid/PUFA ratio (p <0.03). These findings suggest that the V max of LiNa countertransport in erythrocytes is influenced by the lipid composition of the membrane.
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