Melothria maderaspatana mediated one-pot synthesis of cerium-doped Silymarin nanoparticles and their antibacterial and anticancer studies

Abstract

ABSTRACT Cerium-doped Silymarin nanoparticles (Ce-Sil NPs) were synthesised through green methods employing Melothria maderaspatana aqueous extract in a one-pot synthesis. The confirmation of the biosynthesis was evident through a colour change from dark black to brown. Ce-Sil NPs underwent characterisation using UV-Vis, FT-IR, XRD, SEM and EDAX. UV–Visible spectrophotometry detected Ce-Sil NPs at 350 nm. FT-IR analysis revealed the presence of four functional groups in the synthesised nanoparticles: Nitrile, Alcohol (ROH), C-O-C and N-H. XRD analysis indicated that Ce-Sil NPs were more crystalline (82.5%) and less amorphous (17.5%). SEM and EDX spectra offer distinct signals used to detect the morphology of Ce-Sil NPs. Ce-Sil NPs shown noteworthy antibacterial activity when tested against clinical pathogens such as E. coli, MRSA, Pseudomonas aeruginosa and Enterococcus faecalis. Furthermore, at 50 μg/ml concentration, Ce-Sil NPs exhibited a maximum cancer cell death rate (40.6%). These findings suggest that the synthesised Ce-Sil NPs hold promise as potential drugs for future treatments against bacterial infections and cancer.