Abstract
Objective: The aim of this study was to investigate the possible association between the acute to chronic (A/C) glycemic ratio and the presence of erectile dysfunction (ED) in diabetic men. Material and Methods: A total of 104 diabetic men, 45 of whom had ED while 59 did not, were retrospectively enrolled in this study. Clinical examination and laboratory analyses including A/C glycemic ratio, serum fasting glucose, hemoglobin A1c, lipid profile, and total testosterone were analyzed. Results: The total testosterone levels were lower in the diabetic ED patients compared to the non-ED diabetic participants (4.49 ng/dL vs 4.80 ng/dL, respectively). However, the difference was not statistically significant (p=0.093). Mean high-density lipoprotein cholesterol levels were significantly lower in the diabetic ED patients than in the controls (40±9 mg/dL vs 44±10 mg/dL; respectively; p=0.030). Although the median A/C glycemic ratios were higher in the diabetic ED patients (1.28±0.23 vs. 1.18±0.32), no statistical significant differences were noted between the two groups (p=0.054) Conclusion: The strong relationship between diabetes mellitus (DM) and ED demands caution since DM is a common disease in the population. We believe that developing biomarkers for the early diagnosis of ED will help provide treatment and improve the life quality of patients. Although we could not find a statistical relationship between the A/C glycemic ratio and ED in our study results, we think that further welldesigned prospective studies are needed in this area.
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