Abstract
Cancer-associated fibroblasts (CAFs) are an activated sub-population of stromal fibroblast that have the ability to synthesize, deposit and remodel the extracellular matrix. They produce and secrete cytokines and growth factors that promote tumor growth, angiogenesis, inflammation and contribute to drug resistance (Micke and Ostman, 2005). CAFs are abundant constituents of many epithelial tumors. Less is known about CAFs in non-epithelial cancers, such as melanoma, but in vitro data suggest similar roles in tumor development and progression (Kim et al., 2013). This article is protected by copyright. All rights reserved.
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