Abstract
Purpose. To compare the hormone levels of patients with seborrheic meibomian gland dysfunction with controls. Procedures. This is a retrospective case-control study involving 50 patients and 50 controls. Blood workup for hormones was studied in both groups by using macroELISA (enzyme-linked immunosorbent assay). Statistical evaluation was done by using SPSS 15.0 independent samples t-test. Results. There were statistically significant differences of serum testosterone and dehydroepiandrosterone sulphate levels between patients and controls (P = 0.000). Female gender showed statistically significant differences of serum thyroid-stimulating hormone and prolactin levels between patients and controls (P = 0.014 and P = 0.043), in addition to serum testosterone and dehydroepiandrosterone sulphate levels (P = 0.000 and P = 0.001). However, male gender showed statistically significant differences of only serum testosterone and dehydroepiandrosterone sulphate levels between patients and controls. (P = 0.003 and P = 0.003 resp.). Conclusions. Increased serum levels of testosterone and dehydroepiandrosterone sulphate in both genders should be considered as diagnostic markers for seborrheic meibomian gland dysfunction.
Highlights
Meibomian gland dysfunction (MGD) is considered to be a discrete disease entity without prominent inflammatory alterations of the lid margins and a frequent cause of wetting deficiencies of the ocular surface leading to dry eye disease [1]
The effect of androgens on meibomian gland function has been studied in a group of patients with an average of 70.9 years, and androgen deficiency is considered as a critical factor in the pathogenesis of MGD and dry eye [4, 5]
Very little information exists concerning the correlation of serum levels of sex hormones, thyroid hormones, thyroglobulin, cortisol, and prolactin with seborrheic MGD between 20– 30 years of age
Summary
Meibomian gland dysfunction (MGD) is considered to be a discrete disease entity without prominent inflammatory alterations of the lid margins and a frequent cause of wetting deficiencies of the ocular surface leading to dry eye disease [1]. The effect of androgens on meibomian gland function has been studied in a group of patients with an average of 70.9 years, and androgen deficiency is considered as a critical factor in the pathogenesis of MGD and dry eye [4, 5]. The purpose of this study is to compare the serum levels of dehydroepiandrosterone sulphate (DHEAS), testosterone, estrodiol, 17-hydroxyprogesterone (17OH-Prog), prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), bound and unbound thyroid hormones (T3, T4), thyroglobulin, and cortisol between patients with seborrheic MGD and controls in a gender-based design between 20–30 years of age
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