Abstract
Twenty-two children (13 boys and nine girls) with medulloblastoma were seen at Kings County Hospital Center and Brookdale Hospital Center from 1946 to 1968. The tumor was usually located in the cerebellum (21 of 22 cases) and the patients presented with headaches, vomiting, and ataxia; average length of symptoms was three months. No patient survived either untreated (two children) or treated by surgery alone (six children). Five out of 14 children treated by radiation and surgery are alive for periods ranging from 1 to 22 years yielding an actuarial survival of 46% at five years and 35% at ten years. Adequate radiation therapy to the skull yielded better survival (five children of seven alive) than inadequate radiation therapy (none of six alive). Although all tumor recurrences were in the cerebellum, there was no difference in survival with either fractionated doses of 2,500 to 3,000 R in four to nine weeks or doses of 4,000 to 5,000 R in four to six weeks.
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