Abstract

OF DISCUSSION Dr. David Grob, Baltimore : The nerve gases are organic phosphate compounds whose pharmacologie and toxic effects arise from their ability to inhibit the cholinesterase enzymes present in all animal tissues. Two compounds in this group are useful therapeutic agents : di-isopropyl fluorophosphate (DFP), in the management of abdominal distention, urinary retention and glaucoma, and tetraethyl pyrophosphate (TEPP), in the management of myasthenia gravis. The toxic effects of the organic phosphate compounds in animals of all species has led to the use of some of them as agricultural insecticides, including parathion (0,0-diethyl O-paranitrophenyl thiophos'VJV*^AV^A^^Al^JV^ |llEAAAWi«^M /VJ^A^Mr^JWvA^

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