Death due to parathion, an anticholinesterase insecticide.

Abstract

Case Reports1 November 1949DEATH DUE TO PARATHION, AN ANTICHOLINESTERASE INSECTICIDEDAVID GROB, M.D., WILLIAM L. GARLICK, M.D., GEORGE G. MERRILL, M. D., HENRY C. FREIMUTH, Ph.D.DAVID GROB, M.D.Search for more papers by this author, WILLIAM L. GARLICK, M.D.Search for more papers by this author, GEORGE G. MERRILL, M. D.Search for more papers by this author, HENRY C. FREIMUTH, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-5-899 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction in recent years of anticholinesterase (antiChE) compounds as insecticides has led to problems arising from their toxicity for man. The antiChE compound most widely used at the present time is parathion (p-nitrophenyl diethyl thionophosphate).1This anticholinesterase was introduced by the Germans and is now manufactured in this country, chiefly for use as an insecticide in agriculture, under such names as "Geigy Parathion," "Lethalaire G-54 Parathion Aerosol," "Chipman Parathion," "P. A. R. Parathion," "Phos Kit Parathion," "Paradust Parathion," "Dow Parathion," "Vapophos Parathion," "Penphos Parathion," "Aphamite Parathion," "Parathion Insecticides," "Genithion Parathion," "Edco 15 Parathion," and "Niran (Parathion)." Studies performed following...Bibliography1. HALLER HL: Chemical aspects of some of the newer insecticides, Bull. N. Y. Acad. Med., 1949, xxv, 374-381. Google Scholar2. DUBOISDOULLSALERNOCOON KPJPRJM: Studies on the toxicity and mechanism of action of parathion, Jr. Pharmacol. and Exper. Therap., 1949, lxxxxv, 79-91. Google Scholar3. LEHMAN AJ: The major toxic actions of insecticides, Bull. N. Y. Acad. Med., 1949, xxv, 382-396. Google Scholar4. GROBLILIENTHALHARVEYJONES DJLAMBF: The administration of di-isopropyl fluorophosphate (DFP) to man. I. Effect on plasma and erythrocyte cholinesterase; general systemic effects, use in study of hepatic function and erythropoiesis; and some properties of plasma cholinesterase, Bull. Johns Hopkins Hosp., 1947, lxxxi, 217-244. Google Scholar5. GROBLILIENTHALHARVEY DJLAM: The administration of di-isopropyl fluorophosphate (DFP) to man. II. Effect on intestinal motility and use in the treatment of abdominal distention, Bull. Johns Hopkins Hosp., 1947, lxxxi, 245-256. Google Scholar6. GROBHARVEYLANGWORTHYLILIENTHAL DAMORJL: The administration of di-isopropyl fluorophosphate (DFP) to man. III. Effect on the central nervous system with special reference to the electrical activity of the brain, Bull. Johns Hopkins Hosp., 1947, lxxxi, 257-266. Google Scholar7. HARVEYLILIENTHALGROBJONESTALBOT AMJLDBFSA: The administration of di-isopropyl fluorophosphate (DFP) to man. IV. The effects on neuromuscular function in normal subjects and in myasthenia gravis, Bull. Johns Hopkins Hosp., 1947, lxxxi, 267-292. Google Scholar8. GROBHARVEY DAM: Observations on the effects of tetraethyl pyrophosphate (TEPP) in man, and on its use in the treatment of myasthenia gravis, Bull. Johns Hopkins Hosp., 1949, lxxxiv, 532-567. Google Scholar9. MERRILL GG: Neostigmine toxicity. Report of fatality following diagnostic test for myasthenia gravis, Jr. Am. Med. Assoc., 1948, cxxxvii, 362-363. CrossrefGoogle Scholar10. AVERELLNORRIS PRMV: Estimation of 0,0-diethyl 0, p-nitrophenyl thiophosphate, Anal. Chem., 1948, xx, 753-756. CrossrefGoogle Scholar11. LEHMAN AJ: Personal communication. Google Scholar12. GROBGARLICKHARVEY DWLAM: To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication August 16, 1949.Work was performed in part under a contract between the Medical Division, Chemical Corps, U. S. Army, and the Johns Hopkins University.From the Department of Medicine, Johns Hopkins University and Hospital, the Department of Surgery, Mercy Hospital, and the Office of the Chief Medical Examiner, Baltimore, Maryland. 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LEWIS, M.D.PHOSPHATE ESTER POISONING, A NEW PROBLEM FOR THE INTERNIST*DONALD O. HAMBLIN, M.D., JOHN F. MARCHAND, M.D. 1 November 1949Volume 31, Issue 5Page: 899-904KeywordsHospital medicineInsecticideSurgeryToxicity ePublished: 1 December 2008 Issue Published: 1 November 1949 PDF downloadLoading ...