Abstract
<h3>Penicillin Schedule—Not Dosage—May Be Crucial</h3><h3>Reported Failures May Be 'Related To Faulty Timing'</h3> Timing, rather than the amount of the drug given, may be the most important factor in intravenous penicillin therapy, according to Martin E. Plaut, MD, chief of the infectious disease service at Buffalo (NY) General Hospital. "I think many reported failures of penicillin therapy are related to faulty timing," he told Medical News during an interview. "Our studies show that the halflife of penicillin G in the serum of individuals with normal renal function is about 35 minutes. The amount of penicillin in their blood was almost undetectable by the methods used six hours after an injection of 5 million units. When you give such patients bolus injections twice a day, you aren't doing them much of a favor." Dr. Plaut, who is also assistant professor of medicine at the State University of New York
Published Version
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