Abstract
Objective To clarify the mediating role and mechanism of Wnt/PCP-JNK pathway in prevention of neural malformation of taurine.Methods Kunming mouse model of embryonic neural tube defects were induced by using retinoic acid and the animal models of these defects were established by using taurine.Immunohistochemistry,Western Blotting were used to detect Dvl,RhoA,p-JNK/JNK expression of Wnt/PCP-JNK pathway in the neural tube during embryonic development and the relationships among expression changes of various proteins.Results In the control group,no embryos with neural tube defects were observed and low expressions of Dvl,RhoA and p-JNK/JNK were detected by using immunohistochemistry and Western blotting.In the teratogenic group,the incidence of neurological malformation (57.1％) was significantly higher than that in the control group (P ＜ 0.05).Compared with the control group,the expressions of Dvl,RhoA and p-JNK/JNK significantly increased (P ＜ 0.05).The incidence of neurological malformation following taurine treatment was 31.7％,significant lower than that in the teratogenic group (P ＜0.05).The expressions of Dvl,RhoA and p-JNK/ JNK following taurine intervention significantly decreased compared to the teratogenic group (P ＜ 0.05).Conclusion Wnt/PCP-JNK pathway mediates the process for the taurine to prevent the occurrence of neural malformation. Key words: Taurine; Neural tube defects; Wnt signaling pathway; Mice
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