Abstract
The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship between the TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated. A community‐based cross‐sectional study was conducted in 4551 hypertension patients aged 40–75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males. Our study suggested that the TyG index was higher in patients with hyperuricemia than in those without (8.99±0.61, 8.70±0.59, p < .001). The prevalence of hyperuricemia in patients with the lowest (≤8.32), second (8.33–8.66), third (8.67–9.07) and the highest quartile (≥9.08) of the TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index was associated with increased hyperuricemia risk whether in crude or adjusted models (p < .05). Mediation analysis showed that all of our obesity indexes partially mediated the association between the TyG index and hyperuricemia to some extent. In Conclusions, the TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship.
Highlights
Hyperuricemia is caused by abnormal purine metabolism, including excessive uric acid production or insufficient renal excretion, which is one of the components of metabolic syndrome
Conclusion:triglyceride glucose (TyG) index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship
Compared to subjects without hyperuricemia, those with hyperuricemia were more likely to be older in age, with a higher proportion of male, had higher weight, height, Body mass index (BMI), waist circumference (WC), hip circumference (HC), serum TG, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL)-C, uric acid, blood urea nitrogen (BUN) and creatinine, and more Coronary heart disease (CAD) status and stroke history
Summary
Hyperuricemia is caused by abnormal purine metabolism, including excessive uric acid production or insufficient renal excretion, which is one of the components of metabolic syndrome. Previous studies have shown that hyperuricemia is associated with the occurrence and development of many metabolic disorders and cardiovascular diseases. Hypertensive patients with hyperuricemia occurred more cardiovascular events than those without hyperuricemia[1, 2]. Epidemiological study reported that there are 170 million patients with hyperuricemia in China[3], which greatly increases the morbidity and mortality of cardiovascular events. Some studies have reported that IR and obesity are independent risk factors for hyperuricemia, which are significantly related to the occurrence and development of hyperuricemia[4, 5]. It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. The relationship of TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated
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