Meconium-stained amniotic fluid in labor: a randomized trial of prophylactic amniofusion

Abstract

Objectives: To investigate the effect of amnioinfusion in women with meconium-stained amniotic fluid on the rate of cesarian sections and on neonatal morbidity. Study design: A randomized controlled trial. A total of 206 women with meconium-stained amniotic fluid were assigned to receive amnioinfusion via two-way catheter or no amnioinfusion (control group). The catheter was inserted and other treatment was the same in both groups. Results: Amnioinfusion decreased the rate of cesarian sections for fetal distress (RR 0.23, 95% CI 0.07–0.79) and increased mean pH at birth (7.24±0.1 versus 7.21±0.1, P<0.05). It also decreased the frequency of variable fetal heart rate decelerations (RR 0.74, 95% CI 0.59–0.92), and of meconium below the vocal cords in neonates (RR 0.37, 95% CI 0.19–0.69). Conclusions: Amnioinfusion improves the neonatal outcome and reduces the frequency of cesarian sections.