Mechanochemistry’s Role in Nonsteroidal Anti-inflammatory Drugs Development: A Review

Abstract

As a greener method of preparing molecules, mechanochemistry has recently been identified as an ideal strategy for preparing diverse molecules. It is becoming a valuable synthetic tool for multiple fields (e.g., physics, chemistry, and materials science) because it can be performed without solvents or with minimal solvents (catalytic quantities). The use of sustainable methods has been beneficial to several fields of chemistry, including pharmaceuticals, fertilizers, catalysis, organic synthesis, preparation of medicinal solid forms, synthesis of metal complexes, etc. Pharmaceutical and pharmaceutical chemistry will likely be significantly impacted by these developments in medicinal mechanochemistry. Due to their reactivity and materials, they provide materials that are hard to extract from a solution or are not possible. Nevertheless, these technologies could provide the pharmaceutical sector safer, cleaner, and more effective synthetic solutions. The importance of mechanochemical processes in the creation of pharmaceutical cocrystals, especially Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), is discussed in this article.