Mechanochemistry’s role in non-steroidal anti-inflammatorydrugs development: A review

Abstract

As a greener method of preparing molecules, mechanochemistry has recently been identified as an ideal strategyfor preparing diverse molecules. It is becoming a valuable synthetic tool for multiple fields (e.g., physics, chemistry,and materials science) because it can be performed without solvents or with minimal solvents (catalytic quantities).The use of sustainable methods has been beneficial to several fields of chemistry, including pharmaceuticals,fertilizers, catalysis, organic synthesis, preparation of medicinal solid forms, and synthesis of metal complexes.Pharmaceutical and pharmaceutical chemistry will likely be significantly impacted by these developments inmedicinal mechanochemistry. Due to their reactivity and materials, they provide materials that are hard to extractfrom a solution or are not possible. Nevertheless, these technologies could provide the pharmaceutical sectorwith safer, cleaner, and more effective synthetic solutions. The importance of mechanochemical processes in thecreation of pharmaceutical cocrystals, especially non-steroidal anti-inflammatory drugs (NSAIDs), is discussed inthis article.