Abstract
How instantaneous blood flow is controlled in heart is a vexing problem. Here new observations provide compelling evidence for electro-metabolic signaling (EMS). EMS originates in ventricular myocytes (VM's) and is conducted to neighboring capillary endothelial cells (cEC's), to contractile vascular smooth muscle (VSM) cells and to pericytes through gap junctions. Massive ATP production by mitochondria within VM's is able to keep cytosolic [ATP]i at mM levels. Such [ATP]i levels power contractions of VM's which consume ATP at a high rate as they perform pressure and volume work.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
