Abstract
AbstractA complete computational study has been performed in order to rationalise the results of a new organocatalytic approach to the kinetic resolution of 4‐substituted oxazinones which results in highly enantioenriched and orthogonally‐protected β‐amino acids. DFT‐analysis elucidated the preferable binding orientation of the 4‐oxazinone under study, predicted the formation of the observed major R product with a calculated ee in good agreement with the experimental data and allowed a complete mechanistic and stereochemical understanding of the catalysis. The alcoholytic kinetic resolution of a 7‐memebered ring analogue to generate enantioenriched γ‐amino acids was experimentally and computationally investigated for the first time.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
