Mechanisms of Stress-Induced Sleep Disturbance Give New Insight Into Stress Vulnerability

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SEE CORRESPONDING ARTICLE ON PAGE 1138 Nucleus Accumbens Medium Spiny Neuron Subtypes Differentially Regulate Stress-Associated Alterations in Sleep ArchitectureBiological PsychiatryVol. 89Issue 12PreviewStress is implicated in the pathophysiology of major depression and posttraumatic stress disorder. These conditions share core features, including motivational deficits, heighted anxiety, and sleep dysregulation. Chronic stress produces these same features in rodents, with some individuals being susceptible or resilient, as seen in humans. While stress-induced neuroadaptations within the nucleus accumbens are implicated in susceptibility-related dysregulation of motivational and emotional behaviors, their effects on sleep are unclear. Full-Text PDF