Abstract
Extensively hydrolyzed protein products not only provide sufficient nutrition but also effectively reduce the allergenicity of milk proteins. However, there was limited information about the sensitization of extensive hydrolysate of milk protein concentrate (EMPHs). In this study, the mechanism by which EMPHs reduce sensitization was studied by constructing an milk protein concentrate (MPC) sensitization evaluation animal model. The results demonstrated that the serum levels of the specific IgE, IgG and IgG1 antibodies in the EMPH group (O-AX and T-AX) were significantly decreased (P < 0.01). In addition, compared with the MPC group (19.29%), the expression of CD3+CD4+ T cells in the O-AX (16.61%) and T-AX groups (15.94%) was significantly reduced (P < 0.05). This indicated an imbalance of Th1/Th2 in the MPC group, which was confirmed by the results of cytokines and transcription factors in the spleen. The mice in the control MPC group highly expressed FcεRI+CD117+ mast cells (22.25%), peripheral blood B cells (2.91%) and CD3+CD8+ T cells (8.65%). The results indicated that EMPHs did not cause an imbalance of Th1/Th2 cells and Treg/Th17 cells in mice and had lower sensitization.
Published Version
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