Abstract
PURPOSE: Our studies on animal and in vitro models have sought to clarify mechanisms of pleurodesis and produce more specific treatments for recurrent pleural effusions. At CHEST 2007, we presented tissue histology in a rabbit model using talc, doxycycline and blood as sclerosants which demonstrated a significant increase in vascular endothelial growth factor (VEGF) that correlated with pleurodesis in vivo. In this study we evaluated for toxicity and VEGF upregulation in a model of non-transformed human pleural mesothelial cells (MeT-5A) exposed to four clinically-effective sclerosants: talc, doxycycline, erythromycin and human blood.
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