Abstract
Objective: to determine the mechanisms responsible for impairments in the space-time organization of erythropoiesis (SPOE) in experimental sepsis. Materials and methods. The diurnal changes in the titer of erythropoietin, the content of red blood cells, and their distribution by volume, the peripheral blood levels of hemoglobin and reticulocytes, life span, the production of erythrocytes, malonic dialdehyde (MDA), the statokinetic erythroid cell index, and bone marrow 59Fe incorporation were studied in 240 Wistar rats with multimicroial sepsis and 80 intact animals. Results. In sepsis, SPOE desynchronism was found to be due to increases in MDA and in the population of microcytes with shorter life span. The maximum duration was increased for erythropoiesis and decreased for erythrocytic production with the decreased peripheral blood level of ery-throcytes and hemoglobin. The progressive rise in the titer of erythropoiesis was accompanied by decreases in the statoki-netic index and bone marrow 59Fe incorporation with a simultaneous increase in the population of microcytes and with a reduction in the life span of erythrocytes. Conclusion. Endotoxicosis was established to play the leading role in the mechanisms of SPOE desynchronism. Activation of lipid peroxidation in the red blood cell membranes enhances their rigidity, by initiating the development of anemia and microcirculatory disorders. The decreases in erythrocytic production, statokinetic index, and bone marrow 59Fe incorporation with an inadequately high titer of erythropoiesis suggest the inhibition of ery-thropoietin-dependent processes in the target cells, which promotes the progression of septic anemia. Key words: bio-rhythms, erythropoiesis, erythropoietin, anemia, sepsis.
Highlights
Цель исследования — определить механизмы нарушения пространственно временной организации эритропоэза при экспериментальном сепсисе
The diurnal changes in the titer of erythropoietin, the content of red blood cells, and their distribution by volume, the peripheral blood levels of hemoglobin and reticulocytes, life span, the pro duction of erythrocytes, malonic dialdehyde (MDA), the statokinetic erythroid cell index, and bone marrow 59Fe incorpora tion were studied in 240 Wistar rats with multimicroial sepsis and 80 intact animals
space time organization of erythropoiesis (SPOE) desynchronism was found to be due to increases in MDA and in the population of microcytes with shorter life span
Summary
Цель исследования — определить механизмы нарушения пространственно временной организации эритропоэза при экспериментальном сепсисе. Прогрессирующий рост титра эритро поэза сопровождается снижением статмокинетического индекса и инкорпорации Fe59 костным мозгом при одновремен ном увеличении популяции микроцитов и сокращении продолжительности жизни эритроцитов. Статмокинетического индекса и инкорпорации Fe59 костным мозгом на фоне неадекватно высокого титра эритропоэза свидетельствует о торможении эритропоэтинзависимых процессов в клетках мишенях, что способствует прогрессии септической анемии. The progressive rise in the titer of erythropoiesis was accompanied by decreases in the statoki netic index and bone marrow 59Fe incorporation with a simultaneous increase in the population of microcytes and with a reduction in the life span of erythrocytes. The decreases in erythrocytic production, statokinetic index, and bone marrow 59Fe incorporation with an inadequately high titer of erythropoiesis suggest the inhibition of ery thropoietin dependent processes in the target cells, which promotes the progression of septic anemia. Цель исследования — определить механизмы на рушений пространственно временной организации эритропоэза при экспериментальном сепсисе
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