Mechanisms of generation and suppression of oscillations in the basal ganglia

Abstract

Event Abstract Back to Event Mechanisms of generation and suppression of oscillations in the basal ganglia Arvind Kumar1, 2, 3*, Ad Aertsen1, 2, Stefan Rotter1, 3 and Stefano Cardanobile1, 3 1 Bernstein Center Freiburg, Germany 2 University of Freiburg, Faculty of Biology, Germany 3 University of Freiburg, Faculty of Biology, Germany Movement disorders in Parkinson's disease (PD) are commonly associated with slow oscillations and increased synchrony of neuronal activity in the basal ganglia. The neural mechanisms underlying this dynamic network dysfunction, however, are only poorly understood. Here, we show that the strength of inhibitory inputs from striatum to globus pallidus external (GPe) is a key parameter controlling oscillations in the basal ganglia. Specifically, the increase in striatal activity observed in PD is sufficient to unleash the oscillations in the basal ganglia. This finding allows us to propose a unified explanation for different phenomena: absence of oscillation in the healthy state of the basal ganglia, oscillations in dopamine-depleted state and quenching of oscillations under deep brain stimulation (DBS). These novel insights help us to better understand and optimize the function of DBS protocols. Furthermore, studying the model behavior under transient increase of activity of the striatal neurons projecting to the indirect pathway, we are able to account for both motor impairment in PD patients and for reduced response inhibition in DBS implanted patients. Acknowledgements Funded in parts by the German Federal Ministry of Education and Research (BMBF grant 01GQ0420 to the BCCN Freiburg, BMBF GW0542 Cognition, and BMBF 01GW0730 Impulse Control). Keywords: Basal Ganglia and Deep Brain Stimulation Conference: BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011, Freiburg, Germany, 4 Oct - 6 Oct, 2011. Presentation Type: Keynote Topic: other Citation: Kumar A, Aertsen A, Rotter S and Cardanobile S (2011). Mechanisms of generation and suppression of oscillations in the basal ganglia. Front. Comput. Neurosci. Conference Abstract: BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011. doi: 10.3389/conf.fncom.2011.53.00028 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Sep 2011; Published Online: 04 Oct 2011. * Correspondence: Dr. Arvind Kumar, Bernstein Center Freiburg, Freiburg, Germany, kumar@bcf.uni-freiburg.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Arvind Kumar Ad Aertsen Stefan Rotter Stefano Cardanobile Google Arvind Kumar Ad Aertsen Stefan Rotter Stefano Cardanobile Google Scholar Arvind Kumar Ad Aertsen Stefan Rotter Stefano Cardanobile PubMed Arvind Kumar Ad Aertsen Stefan Rotter Stefano Cardanobile Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.