Exploiting basal ganglia tricks to cure its disorders

Abstract

Event Abstract Back to Event Exploiting basal ganglia tricks to cure its disorders Hagai Bergman1* 1 The Hebrew University, Hadassah Medical School Jerusalem, Israel Reinforcement learning models postulate that the basal ganglia networks are built as Actor/Critic network and employ bootstrap temporal difference algorithms to achieve optimal behavioural policy through interactions with stochastic environment and despite delayed and incomplete (scalar) feedback. Continuous high-frequency Deep Brain Stimulation (DBS) is a popular therapy for management of advanced Parkinson's disease – the most common disorder of the basal ganglia. However, since in present DBS systems stimulation parameters are only intermittently adjusted, DBS methods are poorly suited to cope with the fast neuronal and clinical dynamics of Parkinson's disease. We tested the effects of closed-loop stimulation in the MPTP primate model of Parkinson's disease. Closed-loop stimulation has a significantly greater effect on akinesia and on cortical and pallidal discharge patterns than standard open-loop DBS and matched control stimulation paradigms. Thus, closed-loop DBS paradigms have potential not only for the treatment of Parkinson's disease, but perhaps of other neurological/psychiatric disorders in which a clear pathological pattern of brain activity is recognized. Keywords: Basal Ganglia and Deep Brain Stimulation Conference: BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011, Freiburg, Germany, 4 Oct - 6 Oct, 2011. Presentation Type: Keynote Topic: other Citation: Bergman H (2011). Exploiting basal ganglia tricks to cure its disorders. Front. Comput. Neurosci. Conference Abstract: BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011. doi: 10.3389/conf.fncom.2011.53.00030 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Sep 2011; Published Online: 04 Oct 2011. * Correspondence: Prof. Hagai Bergman, The Hebrew University, Hadassah Medical School Jerusalem, Jerusalem, Israel, hagaib@md.huji.ac.il Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Hagai Bergman Google Hagai Bergman Google Scholar Hagai Bergman PubMed Hagai Bergman Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.