Abstract
Over the past decade the study of gastric Hel secretion has undergone several notable advances. Most of these are the direct result of an increasing awareness of developments in fundamental membrane biology and their application to particular problems surrounding acid secretion, such as se cretagogue-receptor activation of the oxyntic cell, membrane transforma tions and turnover associated with the secretory state, transport and electrophysiological correlations, and analysis of membrane-bound enzyme systems as the putative H+ pump. We review recent developments that have come primarily from studies on in vitro preparations, including isolated gastric epithelium, gastric glands, single cells, and various membrane fractions. Our approach largely excludes the voluminous literature on intact animals. Limitations of space have forced us to omit many primary references that have formed the framework of important investigation.
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