Abstract
As a regulated cell death, ferroptosis is different from apoptosis, necrosis and autophagy. Its particularity is lipid peroxide accumulation and mitochondrial size reduction. There are many inducers and inhibitors to regulate the ferroptosis process by regulating the production of reactive oxygen species and the reduction of glutathione-dependent peroxidase 4, which play important roles in ferroptosis. In normal tissues, ferroptosis is characterized by aging and degenerative changes, while in cancer tissues, ferroptosis can be inhibited in many ways, thus promoting the growth of tumors. At present, several drugs have been used to promote ferroptosis in cancer cells, and the combination of traditional therapies is expected to become a new treatment mode. Key words: Ferroptosis; Inhibitor; Inducer; Caner therapy
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