Abstract
Long-lived spin order-based approaches for magnetic resonance rely on the transition between two magnetic environments of different symmetries, one governed by the magnetic field of the spectrometer and the other where this strong magnetic field is inconsequential. Research on the excitation of magnetic-symmetry transitions in nuclear spins is a scientific field that debuted in Southampton in the year 2000. We advanced in this field carrying the baggage of pre-established directions in NMR spectroscopy. We propose to reveal herein the part of discoveries that may have been obscured by our choice to only look at them through the experience of such pre-established directions at the time. The methodological developments that are emphasised herein are the mechanisms of translation between the symmetric and non-symmetric environments with respect to the main magnetic field . More specifically, we look again thoroughly at zero-quantum rotations in the starting blocks of long-lived state populations, magnetisation transfers between hyperpolarised heteronuclei, and protons. These pulse sequences seed subsequent magnetic mechanisms that contribute to further applications. For instance, we show how some of the introduced coherence rotations were combined with classical pulse blocks to obtain two-dimensional correlations between protons and heteronuclei. We hope the pulse sequence building blocks discussed herein will open further perspectives for magnetic resonance experiments with long-lived spin order.
Highlights
This paper is an opportunity to present several magnetic resonance concepts free of particular application-specific introductions
This advance proved relevant for the advancement of long-lived state order (Pileio, 2020; Teleanu et al, 2021; Pileio, 2017; Bengs et al, 2020) and was more challenging to obtain than the two-dimensional spectroscopy application for the study of singlet-state-based exchange we describe in the same paper (SS-EXSY) (Sarkar et al, 2007)
We present from today’s perspective several challenging aspects in the introduction of coherent dynamics designed to render spin order resilient to Chronos’ decrees
Summary
This paper is an opportunity to present several magnetic resonance concepts free of particular application-specific introductions. This may allow such concepts for what they are worth as magnetisation transfer mechanisms and comments on their potential usefulness in further experiments. In the search for new singlet-based excitation sequences (Carravetta et al, 2004) on the route of hyperpolarised magnetisation to long-lived spin states (LLS), we were never tormented by the question “is transport of hyperpolarisation really long-lived?” (Vasos et al, 2009) (Pileio, 2020). The remark, made rhythmic by alliteration, was as concise as it was exact, since the singlet state we were searching for is magnetically inactive, i.e. the spins are “sleeping” This commentary alone may have replaced the introduction to our original paper
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
