Abstract

PARABIOSIS between CBAT6T6 inbred mice with the (CBA × C3H)F1 hybrid (=T6∼F1) (∼ is the symbol for parabiosis) gives considerable latitude in the study of the early phase of non-reactivity (specific immunological tolerance) induced by antigen because the cross circulation develops slowly between the partners1 and the CBA and (C3H inbred mouse strains from which the partners are derived are identical at the H-2 histocompatibility locus. This constitutes a weak antigenic combination and, in conjunction with the gradual appearance of the cross circulation, the resulting (one-way2) immunological reaction between the partners is mild, so that many survive for subsequent study of the mechanism by which tolerance of the foreign antigens present in the hybrid partner is induced in the parental partner.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.