Abstract
Ursolic acid can clear free radicals and prevent the formation of non-enzymatic glycosylation products. Our study assessed the inhibitory effect of UA on the myocardial tissue of mice. 36 healthy mice were equally and randomly divided into 3 groups by double blind method, sham operation group, model group and ursolic acid group. Myocardial injury model was established and treated with ursolic acid followed by analysis of cell morphological structure and apoptosis; levels of serum CK, AST, LDH activity and IL-6, IL-1β and TNF-α levels, as well as expression of p-AKT, AKT and PI3K in myocardial tissue. The morphological structure and apoptosis of ursolic acid group were improved compared to model group (P < 0.05). CK, AST, LDH, p-AKT and PI3K level in serum of ursolic acid group was significantly decreased (P <0.05) along with significantly downregulate IL-6, IL-1β, TNF-α (P <0.05). Ursolic acid ameliorates myocardial injury in mice possibly through inhibition of AKT/P13K signaling pathway to reduce inflammatory cascade in the body.
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