Mechanism of stem cell therapy in animal model of premature ovarian failure

Abstract

In recent years, chemotherapy is the most commonly used for treating malignancies. The female ovaries are sensitive to chemotherapy which may cause premature ovarian failure (POF). Currently, the main treatment of POF is hormone replacement therapy; however, there is still no ideal cure treatment for it. Due to the ability of self-renewal and regeneration, stem cells are thought to be used to treat POF. With the in-depth study, it was found that stem cell treatment of POF may restore ovarian function by paracrine mechanism, anti-inflammation mechanism, anti-ovarian oxidative stress mechanism, ovarian stem cells regeneration mechanism, etc. This article describes the mechanism of mesenchymal stem cell treatment on POF animal models, to provide reference for the clinical treatment of POF. Key words: Premature ovarian failure; Stem cell therapy; Animal models; Mechanisms