Abstract
Abstract A small dose of carbon tetrachloride, equal to 1 20 of an ld 95, administered intragastrically to rats, confers a remarkable protection against subsequently administered and ordinarily lethal doses of the same liver poison. Protection sets in after 12 hours. It is fully developed by 24 hours and lasts for 3 days, after which it gradually fades. The development of tolerance is due to the capacity of the small initial dose of carbon tetrachloride to depress the liver microsomal drug-metabolizing system. Forty-eight hours posttreatment with a small, protective dose of carbon tetrachloride, hexobarbital sleeping time is increased more than 3-fold, and conversion of 14CCl4 to exhaled 14CO2 is depressed to half the control rate.
Published Version
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