Abstract
Summary Rats infested with the ascaridoid parasite Amplicaecum robertsi were found to develop precipitating antibody to worm antigen as early as 24 hours after injection of the parasite. Experiments in vitro showed that the antigen-antibody precipitate was chemotactic to eosinophils. Phagocytosis by eosinophils of the antigen-antibody precipitate occurred and was followed by lysis of the eosinophil granules with discharge of granular material outside the cell. It appears that early antibody production may be responsible for the eosino-philia known to occur in rats infested with Amplicaecum . Mast cell changes were found to follow the local eosinophilia and to occur at sites of eosinophil accumulation.
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