Abstract
The kinetics of oxidation of the chromium (III) complexes, [CrIII(IDA)(Ma)(H2O)]- [IDA=iminodiacetate, Ma=malonic] by N-bromosuccinimide in aqueous solution to yield chromium(IV) has been studied spectrometrically at 25-45°C. The reaction rate increased gradually with increasing pH in the range of (5.75–6.86). The reaction proceeds by one first- order pathway in each reactant. Conformation of the formation of the ternary complex has been done using IR spectrum, TGA, uv-visible spectroscopic and cyclic voltammetry measurements. Thermodynamic activation parameters have been calculated. It is proposed that electron transfer proceeds through an inner- sphere mechanism via coordination of NBS to chromium(III). A common mechanism for this reaction is proposed and supported by an excellent isokinetic relationship between ∆H* and ∆S* values for some ternary chromium(III) complexes.
Highlights
Ternary metal complexes might appear in biological fluids creating specific structure [1,2,3], most frequently manifesting themselves as enzyme-metal ion-substrate complexes[3,4,5,6]
Chromium(III) complexes with nucleotides are used as enzymatic labels by substitution of the activator or inhibitor [7, 8] and finding the role of chromium(III) in transcription processes and RNA and DNA interaction [9]
Transition metal complexes of iminodiacetate have been widely adopted in biology and were gaining increasing use in biotechnology, in the protein purification technique known as immobilized metal-ion [12]
Summary
Ternary metal complexes might appear in biological fluids creating specific structure [1,2,3], most frequently manifesting themselves as enzyme-metal ion-substrate complexes[3,4,5,6]. This explains why ternary system has recently received increasing attention. Iminodiacetic acid is the backbone of hydroxamic acid derivatives that could be used to treat cancer It is useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases [11]. Transition metal complexes of iminodiacetate have been widely adopted in biology and were gaining increasing use in biotechnology, in the protein purification technique known as immobilized metal-ion [12]
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