Mechanism of chirality conversion of crystals by Viedma ripening and temperature cycling

Abstract

Grinding chiral crystals in a saturated solution (Viedma ripening) and changing temperature of crystal suspension (temperature cycling) have become promising methods to convert chirality of crystals, and thereby chirality of molecules under racemizing condition of molecules. We discuss mechanisms of these processes by reviewing proposed mathematical models such as mass reaction rate equations, Becker–Döring models, various Monte Carlo models, and population balance models.