Abstract
A critical stage in the induction of antibody responses is the interaction of antigen molecules with the surface receptors of immunocompetent cells which may result in either immunity, or immune tolerance. The differences between the pattern of antigen binding to B cells in immunity and tolerance are not fully understood. The present communication describes experiments in which binding reaction of dinitrophenylated polymeric flagellin (BNPPOL) with receptor antibody molecules was probed by using other BNP compounds of varying valency and molecular structure as competitive inhibitors. Methods of tissue culture, antibody forming cell assays and antigens used have been described elsewhere(1).
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