Abstract
Feeding glucose to fasted rats resulted in a decrease in the activity of heparin-releasable lipoprotein lipase in heart perfusates. Upon feeding fat to glucose-fed animals the level of heparin-releasable lipoprotein lipase increased 10–14 fold. An immunological titration was used to determine whether the changes in lipase activity following the various nutritional treatments were due to changes in the amount of enzyme present or to activation/inactivation processes. These data suggest that changes in the enzyme activity are due to alteration in the quantity of lipoprotein lipase protein.
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