Abstract
Purified scorpion toxin ( Tityus serrulatus) produced contraction of the isolated rat ileum, followed by an increase in the amplitude of pendular movement and rhythmic variation of tonus. These effects may be due to the release of acetylcholine and substance P. Toxin produced relaxation in the atropinized rat duodenum, which was abolished by alpha and beta sympatholytic drugs. The contraction produced by 5-HT in the rat ileum was either decreased or abolished by toxin. In the toxin-treated ileum, nicotine produced only relaxation. The mechanisms of the inhibitory effects of toxin on the contractions produced by 5-HT and nicotine are discussed. The relaxation produced by nicotine was abolished by alpha and beta sympatholytic drugs and by ganglionic blocking agents.
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